A girl flees her orphanage in a paranoid belief that otherworldly forces are after her. She seeks refuge in the remote town of Fate, Texas, but is met with hostility. The residents are about to enter her Hell.
影片改编自同名畅销童书《Clifford the Big Red Dog》,报告在纽约,小女孩Emily Elizabeth(达比·坎普 饰)获取了一条小狗,这只名叫克里弗的红色狗子乖巧心爱,成为了在黉舍不合群、伶仃的她的好同伙。但狗狗慢慢长成了庞然大物,被一家生物基因公司看上了,Emily和叔叔Casy(杰克·怀特霍尔 饰)必需带着它逃开贪婪之人的追捕。